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At a later time point (17 dpf), SIV vascular pattern was identical in non-irradiated embryos (Figure 5C), indicating that low-dose IR accelerated angiogenic sprouting without causing excessive vessel formation.
Diabetic microvascular disease is pathologically characterized by excessive vessel growth and increased vessel permeability [ 9, 10].
Postnatal EC-specific deletion of α-pv leads to retinal hypovascularization because of reduced vessel sprouting and excessive vessel regression.
Disruption of certain molecular pathways, including the Notch pathway (Phng et al., 2009), will cause excessive vessel regression.
Postnatal-induced EC-specific deletion of α-pv leads to retinal hypovascularization because of reduced vessel sprouting and excessive vessel regression.
The deletion of α-pv in ECs in mice leads to impaired angiogenesis because of both reduced vessel sprouting and excessive vessel regression.
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Loss of function of Unc5b in mouse and zebrafish embryos leads to ectopic filopodial extension from endothelial tip cells and excessive blood vessel branching.
A favorite among the fair-skinned battling ruddy cheeks or excessive blood vessel visibility, the VBeam laser is a go-to.
This makes it an interesting investigatory treatment for cancer, age-related macular degeneration, and other diseases featuring excessive blood vessel deposition.
However, the most prominent feature was excessive subcapsular vessel proliferation with a few hemangioma-like structures.
Higher doses lead to excessive blood vessel pruning producing increased hypoxia, leading to compensatory increase in proangiogenic signals.
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