It may thus be unsystematic and biased [ 4], and may be a component of the (often observed) excessive variability in physicians' prescriptions [ 5, 6], uneasy to explain if one merely looks at evidence-based findings in medical literature.
While the exact causes of excessive variability in a specific repeat tract remain an open question, several features are generally agreed to contribute to high variability of repetitive sequences: length (i.e., number of repeats), purity (i.e., number of interruptions to the repetitive pattern) and sequence (i.e., the nucleotide sequence being repeated) [ 7, 8].
Although the Chairman of the BCBS, Mr. Stefan Ingves indicated that an outline agreement had been reached over the disputed proposals and that the BCBS is "well on track to finalize by the end of its reforms related to reducing excessive variability in risk-weighted assets," no final agreement appears to have been reached.
280 Standard processes should be implemented by local study personnel to enhance data quality and reduce bias by detecting and reducing the amount of missing or incomplete data, inaccuracies, and excessive variability in measurements.
Moreover, such validation tests might have the additional benefit of revealing technical problems, such as excessive variability in RT and PCR efficiency due to RNA quality or inconsistent pipetting.
Excessive variability in myofiber size was evident with a pattern of degeneration (multifocal groups of necrotic fibers with variable phagocytosis) and regeneration (multifocal groups of small calibre fibers with a basophilic appearance and of histochemical type 2C).
Lack of information independent from commercial influences, limited efforts to actively implement evidence-based information and its limited comprehensibility are important determinants of this gap and may influence an excessive variability in physicians' prescriptions.
Although detailed information about food consumption was not collected in this outpatient study, the overall between-subject variability in CL/F (39.4%) and residual error (33%) estimated with the population PK analysis were reasonably low, suggesting that any variation in the way patients took evacetrapib with respect to meal conditions did not result in excessive variability in exposure.
Across all trial years, a total of seven trials were lost due to planter issues, excessive moisture interfering with planting and/or harvest, bird or deer damage, weed pressure, excessive variability, or uncertainty about the actual treatment allocation.
