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Our hypothesis to explain the AMD/FI association is straightforward: increased complement alternative pathway activity in the retina results from or is secondary to low FI levels; i.e. for a given degree of retinal injury or damage, there is an excessive (undesirable) degree of complement activation which is particularly damaging to the retina.
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Capillary leak represents the maladaptive, often excessive, and undesirable loss of fluid and electrolytes with or without protein into the interstitium that generates anasarca and end-organ oedema causing organ dysfunction and eventually failure [9].
On the contrary, some stress originates from excessive or undesirable constraints that can produce obstacles to personal growth and accomplishment; these are defined as hindrance stress (Cavanaugh et al., 2000).
In addition to the dopamine system, the noradrenaline and histamine system are also related to ADHD [ 33]. "Hypersensitivity" refers to excessive and undesirable reactions produced by the normal immune system, and includes both allergic and non-allergic anaphylaxis [ 30].
TNFα in macrophages may be required to suppress undesirable excessive inflammation and scarring, both of which are promoted by transforming growth factor β, and for restoration of tissue architecture in a healing alkali-burned cornea in mice.
Hence, it is very necessary to control these undesirable excessive vibrations of bridge under train loads.
To suppress the undesirable excessive responses of the bridge, different TMFD systems are employed.
Slight expansion may contribute to superior sealing ability, but excessive expansion is undesirable when the material is employed as a root canal filling material as it may elicit cracks in the root [ 21].
Noise, defined as unwanted or excessive sound, is an undesirable by-product of today's society.
Excessive temperature rise is undesirable for performance as well as reliability.
This led to unacceptable scratching and surface finish in the produced endcaps, resulting in an excessive scrap rate and undesirable finishing operations in order to repair the defects, when possible at all.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com