Since the remodeling of Ca2+ signaling contributes to cancer hallmarks such as excessive proliferation, survival or resistance to cell death18, we focused on genes belonging to the Ca2+ signaling toolkit19.
Mechanical loading is critical for flap survival: excessive tissue tension reduces blood supply and induces tissue necrosis.
Although it is demonstrated that autophagy is required for T cell survival, excessive autophagy seems to be destructive for T lymphocytes.
Although nutrients are essential for the regulation of many physiological processes and are required for organismal survival, excessive caloric intake can lead to diabetes, cardiovascular disease, and certain forms of cancer [ 12].
Since Rogoff seems to have decided to mention my excessive pessimism about euro survival as often as possible, I think it's important to be clear about what I got wrong.
OBJECTIVE: Inducible nitric oxide synthase, a protein product of NOS2A, generates nitric oxide as a defense mechanism, but excessive levels threaten cellular survival.
Such finfish must be protected from excessive freshwater introduction for survival.
We attempted to treat mice with aNF (with or without tranilast) to block AHR activation, but because of excessive toxicity and poor survival these experiments could not completed.
ER stressors can induce autophagy-dependent survival; however excessive level of stress results in apoptotic cell death.
Physiological levels of ROS lead to growth adaption and survival; however, excessive ROS cause irreversible cellular damage, thus provoking autophagy and/or apoptosis [ 18, 19].
