Exact(1)
This model of excessive salience has been linked to dopaminergic dysregulation and has been invoked to account for both the symptoms and the characteristic response to treatment (Kapur, 2003).
Similar(7)
We caution that, although potential interaction might possibly seem to imply that CRF antagonists could be used therapeutically to reduce excessive incentive salience in stress, the actual effect of CRF receptor manipulation on dopamine release in nucleus accumbens may involve complexities that could complicate such predictions.
"So not excessively excessive.
These neuroadaptations are said to endow an excessive attribution of incentive salience to both the drug and drug-associated stimuli, making addicts compulsively 'want' to take drugs again.
If increased lever pressing for reward is caused by excessive attribution of incentive salience to the reward's CS+, then the temporal pattern of peaks of cue-triggered responding should be phasic, reversible, and repeatable [ 30, 31].
The increase in cue salience that is mediated by increased D1 receptor density, rather than excessive cocaine experience, appears to underlie the transition from aversion to reward in cue-induced neural response and may form the basis for habit-forming vulnerability.
Addictions can consist of excessive behaviors of all types, and some factors can be argued to be present in all types of addictions (e.g., salience, tolerance, withdrawal, conflict, and relapse) [ 17].
(Psychologists call this the "salience bias").
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