Having three different forms of phosphoinositide may seem an excessive requirement for controlling lysosomal tubulation.
The selective application of excessive requirements by, for example, Brussels and Washington will simply be an exercise in futility, and possibly dangerous.
My view is we can find a fair solution but without excessive requirements.
Through computational experiments, we establish that the known formulation has excessive computational requirements for large-scale problems, whereas the alternative model constitutes a basis for an efficient heuristic.
Here, the QR factorization can also be obtained directly using the MATLAB built-in command qr but it is not preferable due to its excessive storage requirements for orthogonal matrix Q and by not necessarily providing positive sign of diagonal elements in the matrix (R_{2}) [12].
In de-novo phylogenetic inference methods, the run-time increases at least log-linearly with the number of homologs or they rely on time-consuming optimizations of parameter-rich phylogenetic models, which generates excessive computational requirements for the analysis of Gb-sized NGS samples.
Hence, the computational time may become too excessive to satisfy the requirements for interactive design in CAD.
The incidence of excessive postoperative bleeding and transfusion requirements for major cardiac surgical interventions varies between 10% and 70%.
Just as too much medication is not necessarily more effective in combatting a disease, but might even be dangerous, such is the case with excessive reporting, compliance and other bureaucratic requirements for scientists.
In January, all but two teams of the dogs (whose overall numbers had been depleted by mishaps and illness in the preceding months) were shot on Shackleton's orders, because the dogs' requirements for seal meat were excessive.
