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The official said the UK government felt there was now an "increased likelihood" that the weapons parts could be used in the excessive repression of protesters in the near future.
These data suggest that excessive repression of the LXR/RXR complex on the ABCA1 promoter, which can be overcome by treatment with an LXR agonist, may be responsible for its reduced transcription in cells lacking LRP1.
The DRM transcription factor complex, named for its Dp/E2F, Retinoblastoma-like, and MuvB subunits, affects germline gene expression and prevents excessive repression of X-chromosome genes.
In C. elegans germ cells, DRM predominantly localizes to autosomes, yet loss of the DRM subunit LIN-54 leads to excessive repression of X-linked genes (Tabuchi et al. 2011).
First, excessive repression of PERK, as a kinase involved in a generic cellular stress-response pathway, could hamper the ability of neurons to respond to cellular stress and could disrupt normal regulation of protein synthesis, thereby causing synaptic dysfunction.
At the same time, we should be cautious about applying this therapeutic strategy and be mindful not to disrupt the cellular and synaptic homeostasis by excessive repression of PERK-eIF2α signaling.
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Stalin's paranoia, Mr. Montefiore observes, was "part of a personal vicious circle that was to prove so deadly for many who knew him": "His radical policies led to excessive repressions that led to the opposition he most feared.
Coupled with those older values were qualities that we don't want to revive: intolerance, fatalism about one's place in the world, excessive stoicism, repression, bigotry and the exploitation of women and minorities.
reduced affective regulation ability, in particular anger, towards which the patient with headache shows excessive inhibition-repression and/or inward directedness [9, 10].
This vulnerability is characterized by (a) ineffective coping styles (internal coping, social avoidance and isolation, pessimism, poor perception of event predictability or control), and (b) reduced affective regulation ability, in particular anger, towards which the patient with headache shows excessive inhibition-repression and/or inward directedness [9, 10]. .
This excessive violence and repression by the government has sadly become routine in Iran – but has not deterred the Mourning Mothers.
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