Sentence examples for excessive replication from inspiring English sources

However, this mechanism is only performed if the distance from the requester to the replier is at least of four hops away in order to avoid an excessive replication of the documents in the neighbour nodes.

It seems a senescent-like, pro-inflammatory fate can be acquired in response to intra- or extracellular danger signals, inflammation, infection, excessive replication, or toxic metabolites.

This would be expected to set up a positive feedback loop, with premature and thus excessive loss of adult cells driving excessive replication and differentiation in the stem cell compartment.

Treatment of U2OS cells with a small molecule WEE1 inhibitor MK-17755) has been shown to result in loss of phosphorylation-dependent CDK1 inhibition and increased rates of DNA synthesis due to excessive replication initiation.

Thus, type I IFN may restrict excessive viral replication in the early phase of infection but does not seem to play a major role in subsequent viral clearance.

Many of these cases had excessive virus replication in the lungs and, less frequently, virus spread to extra-respiratory organs, but mechanisms of virus spread to the brain remain unclear.

Then, metabolic abnormalities occur following excessive DNA replication, which would result in genomic instabilities.

Surprisingly, however, this poorer outcome was not explained by impaired type-I IFN production in the CNS, or by excessive virus replication in target tissues.

We conclude that blockade in STAT-1 activation, leading to inhibition in the expression of critical IFN-dependent antiviral genes, accounts for excessive RSV replication leading to apoptosis of LNCaP cells.

Results from Figure 9 demonstrate that IFN plays an important role in limiting RSV infection in RWPE-1 and PC-3 cells, whereas lack of this restriction in LNCaP cells associated with excessive viral replication and oncolysis.

We have recently identified RSV as an oncolytic virus by demonstrating that RSV can cause apoptosis of PC-3 human prostate cancer cells in culture and in a xenograft tumor environment as a consequence of excessive viral replication in PC-3 cells that led to apoptotic cell death [ 7].