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A cytokine-leptin link hypothesis has also been suggested as a contributing factor to cirrhotic hyperleptinemia; presumably activated tumor necrosis factor-α (TNF-α) in cirrhosis can cause excessive release of leptin from adipose tissue [ 26].
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This, in turn, causes excessive release of the neurotransmitter glutamate [18].
The excessive release of wastewater into the environment is a major concern worldwide.
Global cerebral ischemia (GCI) causes energy deficiency results in excessive release of glutamate from neurons.
9 10 Continuous irritation of the endplates leads to excessive release of acetylcholine.
Excessive release of these cytokines is an important part of inflammation in AD.
The hyper-inflammatory phase in sepsis is characterized by excessive release of various cytokines [ 24, 25 ].
An excessive release of free Trp could undermine pregnancy by abolishing T-cell suppression by Ks.
However, excessive release of these cytotoxic products can further damage an injured tissue.
Excessive release of ROS powers over this system resulted in organ damage.
Thus, excessive release of Ca2+ from the ER may play an important role in excitotoxicity.
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