Sentence examples for excessive prolongation from inspiring English sources

These biophysical properties of the mutated sodium channel can also explain excessive prolongation of QT interval in response to bradycardia at rest, and a shortening of repolarization during sinus tachycardia in freely roaming ΔKPQ-SCN5A mice in this study.

* norepinephrine was the only inotropic or vasopressor medication used in any study patient ** excessive prolongation of the QTc interval, necessitating drug discontinuation CI = confidence interval; ICU = intensive care unit; QTc = QT interval corrected for heart rate.

By design, the study found doses that were not well tolerated; three patients receiving the 0.75 and 1.0 mg/kg/h doses developed signs and symptoms of myocardial ischemia most likely due to excessive prolongation of the systolic ejection time, causing decreased diastolic coronary perfusion and decreased diastolic filling.

In December 2010, the US FDA prohibited use of IV dolasetron for CINV because of excessive QTc prolongation.

Further modifications have been made: thioridazine has been moved from risk category 3 to 2, as it was withdrawn from general use in 2005, due to association with excessive QT prolongation and cases of TdP.

Electrophysiologic studies with prucalopride on ion-channel currents in isolated cardiac cells showed that the drug had a lower affinity for the cardiac potassium HERG channel than does cisapride, a prokinetic that is associated with a risk of torsade de pointes arrhythmias due to excessive action potential prolongation through HERG-channel inhibition.

"So not excessively excessive.

Four of the ten patients experienced postural hypotension, which resolved over time; six patients lost weight (average 5.2 pounds); and excessive sedation and QTc prolongation were not reported.

In the light of non-definitive data, how should we treat a patient with HF and CI? Cognitive enhancing medication such as acetylcholinesterase inhibitors have recognised effects on the cardiac conduction system, occasionally causing bradycardia, sick sinus syndrome or other arrhythmias (including torsades de pointes) resulting from QT prolongation through excessive cholinergic stimulation.

Relatively simple interventions, like the one assessed in this study, should be implemented in all hospitals with excessive lengths of stay, since unnecessary prolongation may be harmful to patients.

The subsequent survival was linked to the dose received during exposure to light, and results were obtained on the environmentally induced prolongation of survival, maintenance of population or excessive growth, at 4 °C, 20 °C and 37 °C, respectively.