Exact(6)
While the consequences of oxygen deprivation are well known, we also know that excessive oxygenation creates new problems because hyperoxia exacerbates lung injury.
Several therapeutic options that limit the harmful effects of hyperoxia can be contemplated, but prevention of excessive oxygenation is likely to be the most effective strategy.
However, excessive oxygenation also has deleterious properties in various pathophysiological processes and consequently both clinical and translational studies investigating hyperoxia during critical illness have gained increasing interest.
While avoiding hypoxemia has long been a goal of critical care practitioners, less attention has been paid to the potential for excessive oxygenation.
Excessive oxygenation may be most intensively studied after resuscitation from cardiac arrest as both the vascular alterations and the ischemia and reperfusion injury are hypothesized to be hazardous [ 58].
This study shows that most clinicians acknowledge the potential adverse effects of prolonged exposure to hyperoxia, in accordance with emerging evidence for pulmonary toxicity and increased risk of poor outcome in both humans and animals caused by excessive oxygenation [[ 2],[ 4],[ 6],[ 8],[ 16],[ 18],[ 20],[ 35],[ 44]].
Similar(54)
During the initial 16 h following traumatic brain injury, strong correlations were found between extracellular fluid neurofilament heavy chain levels and physiological parameters (systemic blood pressure, anaerobic cerebral metabolism, excessive brain tissue oxygenation, elevated brain temperature).
"So not excessively excessive.
Administration of NO does need to be continuous for PVR reduction, and a potential exists for worsening oxygenation at excessive doses [ 248].
Factors that contribute to causation and perpetuation of the chronicity of wounds include repeated trauma, poor perfusion or oxygenation, and excessive inflammation [ 3].
In contrast, "boosting" ScvO2 by excessive transfusion, inotropic support or oxygenation might abrogate this protective mechanism [ 3].
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