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Alternatively, the presence of supernumerary RFs as a consequence of excessive origin firing has been suggested to lead to the depletion of dNTP pools and cause RF stalling/collapse (Jones et al. 2012).
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It is possible that the band read the comic books, but excessive readings the origin story to find direct correlations are bit of a stretch.
This may seem picky, but the inconsistency rankles only because Krol has set up the manuscript's origin with excessive specificity.
These considerations prompted us to focus on elucidation of the origins of excessive complexity and of nonessential genes.
When cells are forced to fire an excessive number of replication origins, the demand for replication factors increases dramatically, and it is potentially disastrous to initiate replication using a replisome missing critical components that have become limiting.
Patients with injuries due to excessive heat of man-made origin (ICD-9-CM E900.1) were not included.
Although excessive weight gain, regardless of origin, is of concern due to its association with physical health problems, the current findings suggest that patients who have greater treatment-emergent weight gain are more likely to benefit from treatment with olanzapine or haloperidol.
Systemic sclerosis or scleroderma (SSc) is a connective tissue disease of unknown origin characterized by excessive deposition of collagen and other extracellular matrix components in skin and visceral organs, severe alterations in the microvasculature, and humoral and cellular immunologic abnormalities [ 1, 2].
Some cases of excessive fears may have their origins in unpleasant experiences during early life.
But the two fell out over Freud's excessive emphasis on the sexual origins and content of neurosis.
Indeed in the fission yeast frequent DSBs arise in origin regions under conditions of excessive firing.
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