Sentence examples for excessive lethality from inspiring English sources

Unfortunately, all of the above approaches failed due to excessive lethality and we were thus unable to replicate the rescue experiment using a vg-independent method.

"So not excessively excessive.

We also propose a role for Ubp3/ Blm3 in protection based on its central position and connection to SSA1 and SSA2 in the upregulated protein network and the excessive chromosomal damage and lethality in blm3 -1/ blm3 -1 cells.

Conversely, Hilfiker-Kleiner et al have reported that mice displaying heart-specific enhanced STAT3 activity due to the expression of a mutated intracytoplasmic sequence of mouse gp130 (gp130Y757/fl) showed excessive inflammatory responses and lethality upon myocardial infarction (Hilfiker-Kleiner et al, 2010).

Our patients presented classical features of JS including the MTI of varying severity, without lethality or demonstrable excessive fetal wasting in affected families.

We previously reported that the simultaneous loss of PLC δ1 and PLC δ3 caused embryonic lethality because of excessive apoptosis and impaired vascularization of the placenta.

Since the Glu transporters are indispensable for normal brain development and function, knocking out two transporter genes in a mouse leads to excessive brain damage and embryonic lethality [ 15].

While both loss of SUMO conjugation as well as excessive SUMOylation results in embryonic lethality [ 28, 29], more subtle changes of the SUMOylation machinery lead to deregulation of multiple cellular pathways including those with relevance for cell proliferation and differentiation [ 10].

These potential advantages conferred by genomic instability to the tumour cells must be balanced against the selective disadvantage, which can result from the generation of large numbers of cells with deleterious mutations or tumour lethality conferred by excessive chromosomal instability in animal models (Weaver et al, 2007).

Unfortunately, the simultaneous loss of PLC δ1 and PLC δ3 results in embryonic lethality because of excessive apoptosis of placental trophoblasts and impaired vascularization of the placenta, which hampered our investigation into the role of the PLCδ1 and PLCδ3 genes in the cardiovascular systems in adult animals.

Therefore, caspase-7-deficient mice were resistant to LPS-induced lymphocyte apoptosis and were markedly protected from LPS-induced lethality independently of the excessive production of serum cytokines.