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However, an excessive influx and persistence of these inflammatory cells may also lead to corneal destruction2.
Previous reports have suggested that excessive influx of Ca2+ to myocytes indicates muscle cellular damage in muscular dystrophies22,23.
Ms. Keller, who is German, said the real justification for the Smart Borders package was to prevent an excessive influx of refugees from the Arab world or other regions in crisis.
Polyploidy is believed to facilitate increased plant adaptability to environmental extremes, and thus characterizing the developmental and morphological changes in roots of polyploid rice that protect against the excessive influx of Na+ is important.
This can lead to excessive influx of sodium, which prompts reversal of the sodium-calcium exchanger.
Although appropriate Th1 cell traffic into the inflamed liver is necessary to eliminate microorganisms, 14 excessive influx of Th1 cells may cause more severe inflammation.
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We demonstrated through in vitro contraction that excessive Ca2+ influx is one of the earliest events to occur in intact dystrophin-deficient muscle in response to electric stimuli.
These analyses suggest that TRP family Ca2+ channels partially mediate the excessive Ca2+ influx that provokes skeletal muscle cellular damage in DMD-Myocytes.
Nimodipine is an L-type calcium channel antagonist that reduces excessive calcium influx during pathological conditions (contributing to its neuroprotective properties).
Thus, our study reinforces previous findings and shows that excessive Ca2+ influx into intact myotubes under contraction is indeed one of the primary and cell-autonomous phenotypes of DMD.
Under these conditions neuronal damage derives from excessive Ca2+ influx and reactive oxygen generation.
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