Sentence examples for excessive gene expression from inspiring English sources

Excessive gene expression can be particularly harmful if it occurs in a vulnerable organ such as the lungs as they are essential for physiological respiration.

Ever since the discovery of RNA interference (RNAi), which is a post-transcriptional gene silencing mechanism, researchers have been studying the therapeutic potential of using small interfering RNA (siRNA) to treat diseases that are characterized by excessive gene expression.

According to the hypothesis 1, a fraction of each population is essentially pre-pathological due to insufficient or excessive gene expression.

Excessive gene expression in testes can be explained by a permissive state of chromatin in testes owing to the peculiar properties of transcription in meiotic and postmeiotic cells ("out of testis" hypothesis; Kaessmann 2010).

Interestingly, for optimal cognitive performance CREB-dependent transcription must be maintained within a limited range; hence, excessive CREB-mediated gene expression has been shown to interfere with hippocampal-dependent learning and memory [32].

The virtual lack of lines that suppress sev-stbm could also be a consequence of excessive non-specific gene expression in the GMREP lines, although this possibility is not supported by the results of an independent screen, in which 250 deletion lines also failed to suppress sev-stbm ([25]).

These network patterns show that genes are generally affected by multiple direct or indirect regulators, and the presence of FFL acts to minimize excessive fluctuations in gene expression, thus contributing to the stability of the whole biological system and robustness against noise [ 8, 17].

To identify TFs contributing to aberrant KC activity, including abnormal differentiation and excessive proliferation, we evaluated gene expression in psoriasis lesions from a meta-cohort of 237 patients.

The expression of T-regulatory cells, which mediate immune tolerance and abrogate excessive inflammation, is linked to Foxp3 gene expression.

The DRM transcription factor complex, named for its Dp/E2F, Retinoblastoma-like, and MuvB subunits, affects germline gene expression and prevents excessive repression of X-chromosome genes.

These responses would suggest to us that the exogenous insulin interacts with excessive cytokine signalling to influence skeletal muscle gene expression.