Excessive expression of T-bet represses Bcl-6 expression and interferes with Tfh cell expansion and GC formation7,9.
Arai, Y., Ijuin, T., Takenawa, T., Becker, L. E. & Takashima, S. Excessive expression of synaptojanin in brains with Down syndrome.
Conclusion: ECRS and NECRS can be considered diseases of excessive expression of cysteinyl LTs.
Chitin patch caused less inflammation by inhibiting excessive expression of IL-6 and TNF-α when compared to the polypropylene mesh (P < 0.01).
To avoid mislocalization of ILK by its excessive expression, mEmerald-ILK cDNA was placed downstream of the TRE3G promoter, and expression was induced by the addition of 10 nM doxycycline 1 h after plating.
The Mayor observed dryly that the competition is "given to excessive expression of their ability". He practiced during the week by playing with BJORN BORG, who was visiting the city.
Pro-inflammatory cytokines are involved in the pathogenesis of many inflammatory diseases, and the excessive expression of many of them is normally counteracted by glucocorticoids (GCs), which are steroids that bind to the glucocorticoid receptor (GR).
One of the major neurobiological mechanisms proposed in drug resistant epilepsy is removal of anti-epileptic drugs (AEDs) from the epileptogenic tissue through excessive expression of multi-drug efflux transporters such as P-glycoprotein (P-gp).
We used these two plasmids to balance the expression levels of PtxD and HtxABCDE, since we observed that high expression level of PtxD was required to support faster growth in MOPS-Pt, whereas excessive expression of HtxABCDE was detrimental to the cell growth (Supplementary Fig. 1).
It has been a long journey for the kaftan, an item first depicted in the art of ancient Persia from around 600BC, that was to reach its most luxurious, excessive expression first in the magnificence of the early Ottoman empire, worn by sultans, then on the back of Liz Taylor, and finally at the rock festivals of the early 21st century, flung over ripped denim shorts.
To further compound the problem, results from all investigative trials (with one exception) have shown that tested immunotherapies aimed at modulating the excessive expression of key cytokines, such as the interleukins and tumor necrosis factor, have been either equivalent or inferior to placebo.
