"So not excessively excessive.
Excessive cash release for developmental projects is aggravating the effect of corruption on donor funded projects.
As described, chd2 morpholino-injected larvae displayed body curvature, excessive body pigmentation, and developmental delay (Suls et al., 2013).
When caloric intake is excessive, particularly at critical developmental stages, physiologic priorities are set for body growth and fecundity rather than for endurance and longevity.
This may be caused by excessive CR during the developmental age, because 40% CR caused higher mortality early in life, but lower mortality late in life, with the longest lived 8% of mice all coming from the CR wild-caught rodents.
Our results showed that neonatal heart failure through HSP60 induction likely involves developmental defects and excessive apoptosis.
MIC-CAP syndrome, diagnosed at or shortly after birth, is characterized by severe microcephaly (a condition in which an infant's head is significantly smaller than the heads of other children of the same age and sex) with progressive cortical atrophy, intractable epilepsy, profound developmental delay, and excessive small capillary malformations on the skin.
More recently, studies of human developmental syndromes established that excessive activation of RTKs and their downstream signaling effectors, most notably the Ras signaling pathway, can also lead to structural and functional defects.
Such a distinction between "developmental" catch-up and excessive weight gain could furthermore explain some discordant results on the relationship between birth measurements and the metabolic risk.
Prader Willi syndrome exhibits developmental defects, cognitive disabilities, excessive eating and life-threatening obesity.
