Sentence examples for excessive deleterious from inspiring English sources

We did not list specific disease-causing mutations in our paper--instead, we detected a general pattern that domestication leads to increased levels of inbreeding and accumulation of excessive deleterious mutations in modern horses".

Preclinical animal models of inflammation and infections have become important tools for improving our understanding of the regulation of inflammatory reactions in general and for the development of novel treatment strategies to modulate excessive, deleterious inflammatory reactions.

Although TE transposition appears to be suppressed in rice infecting strains, we suggest that M. oryzae cellular machinery allows limited TE movement enabling loss of avr genes, but at the same time utilizes small RNA silencing machinery to ensure genome integrity and avoid excessive deleterious mutations.

Excitotoxicity, due to excessive and deleterious calcium influx into cells, has long been recognised as a common mechanism underlying the range of neurodegenerative diseases including Alzheimer's, Parkinson's and Motor Neuron diseases [1] [4].

Genetic drift thus would fix excessive slightly deleterious mutations in synonymous sites, due to Hill-Robertson interference among linked loci.

Such an effect of genetic drift can also produce a pattern of 'fast-Z' evolution, through fixation of excessive slightly deleterious mutations on the Z chromosome.

Organophosphates (OPs) are highly toxic chemicals, which mainly exert their toxicity by irreversible inhibition of acetylcholinesterase (AChE) and the consequent excessive and deleterious buildup of acetylcholine (Maxwell et al. 2006).

We find the effective population size of Z chromosome is significantly reduced than that of autosomes under the neutral expectation, and such a reduction probably results in fixation of excessive slightly deleterious mutations by genetic drift on the Z chromosome, producing a pattern of 'fast-Z' evolution across different bird species.

We will then outline their potential pathogenic role in autoimmunity as well as their homeostatic role in suppressing excessive immune responses deleterious to the host.

Regulatory T cells play an important role in the maintenance of immunological unresponsiveness to self-antigens and are involved in suppressing excessive immune responses deleterious to the host.

Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host.