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At such telomeres, Mec1/Ddc2 will bind near telomeres and can, assuming resection is not excessive, contribute as a back up mechanism for telomere protection that only engages if Tel1 fails to recruit telomerase activity to short telomeres (dashed arrow between Figure 1G and H).
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However, the mechanisms by which PMN eradicate offending bacteria are non-specific and can lead to tissue damage which, if excessive, contributes to the pathology of the disease.
In remarks after the speech, the American described as "excessive" the pace of fiscal adjustment "It has been excessive and contribute to this dramatic contraction of the economy," he told me.
Excessive caseloads contribute to this trend, and result in a "meet 'em and plead 'em" system of justice, in which clients have little more than a brief conversation in the courtroom with a harried public defender before pleading guilty.
Richardson admitted that excessive partying contributed to their undoing.
The excessive weight contributed to the pilot's inability to stop his helicopter from spinning out of control, it said.
In the Lewis case, an inquest found he was killed by prolonged restraint on a mental health ward involving up to 11 police officers and the inquest jury concluded that excessive force contributed to his death.
The mother of a young man who was killed by prolonged restraint on a mental health ward has called for the police officers involved to be prosecuted, after an inquest concluded that excessive force contributed to his death.
"Drinking at these excessive levels contributes to a range of medical conditions including cancers, cardiovascular diseases, diabetes, gastro-intestinal diseases, neuropsychiatriac disorders as well as accidental injury and video".
These excessive ROS contributed to hepatocyte necrosis.
Excessive pronation contributes to the development of abnormalities of the first metatarsophalangeal joint, due to increased weight transmission medially across the foot [ 4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com