Sentence examples for excessive complement from inspiring English sources
It has been proposed that, in preeclampsia, expression of these regulators is reduced, leading to excessive complement activation with generation of excess anaphylatoxins and a resulting proinflammatory maternal-fetal environment [ 20].
Excessive complement activation can result in extreme tissue damage and systemic inflammatory responses, similar to innate immune responses rapidly elicited after systemic adenovirus (Ad) injections.
There are several mechanisms by which malaria may induce excessive complement activation, thereby contributing to the pathophysiologic mechanisms underlying PM.
However, excessive complement activation contributes to undesired tissue damage and the role of complement in other inflammatory diseases has previously been reported [46].
Thus, excessive complement activation with subsequent generation of C5a has been coined "too much of a good thing" [29] or "the dark side of C5a in sepsis" [30].
Based on the hypothesis that excessive complement activation may contribute to PM, in particular generation of the potent inflammatory peptide C5a, we investigated the role of C5a in the pathogenesis of PM in vitro and in vivo.
The former can be associated with excessive systemic complement activation from dysfunctional CFH, while the latter two are associated with mutations affecting the ability of CFH to bind to anionic surfaces such as on endothelial cells and glomerular and retinal capillary walls.
Excessive systemic complement activation with liberation of C5a has a number of concomitant detrimental effects both directly and through other inflammatory and hemostatic mediators [ 30].
In patients with factor H deficiency, soluble recombinant CR1 may block immediately the excessive activation of complement and restore C3 levels [84].
PTX3 can bind to component C1q and thus prevent unwanted excessive activation of complement [ 6].
Despite this protection, excessive or inappropriate complement activation has been associated with inflammatory responses in immune complex-dependent diseases and in adult respiratory distress syndrome [ 7, 8].
