Sentence examples for excessive cholesterol from inspiring English sources
It didn't hurt that a number of the drugs introduced in those years were breakthrough therapies for widespread problems like high blood pressure, excessive cholesterol and depression.
The prize was awarded as scientists began warning that excessive cholesterol could contribute to circulatory diseases like atherosclerosis, in which the arteries narrow, leading to a heart attack or a stroke.
Reduced ABCA1 expression in the aorta of smLRP1−/− mice thus results in impaired cholesterol efflux and contributes to the excessive cholesterol accumulation in vivo.
Excessive cholesterol however, is implicated in atherosclerotic lesions and gallstone formation [ 49].
Thus, tegaserod, acting on 5-HT4 receptor, ideally should obviate detrimental effects of excessive cholesterol on gastrointestinal smooth muscle.
Excessive cholesterol must be rid itself of the body via its transportation to liver for biliary excretion.
Because the link between excessive LDL cholesterol and cardiovascular disease has been so widely accepted, the Food and Drug Administration generally has not required drug companies to prove that cholesterol medicines actually reduce heart attacks before approval.
A possible alternative mechanism may be related to the toxicity of excessive hepatocellular cholesterol and the consequent mitochondrial damage in carriers of the E167K variant [ 95, 96].
It is not only important in the pathogenesis of cardiac diseases but insufficient or excessive cellular cholesterol results in several pathological processes including diabetes, atherosclerosis, metabolic syndrome and neurodegenerative diseases like Alzheimer's.
To protect cells from the toxicity that would result from excessive non-esterified cholesterol accumulation, the non-esterified cholesterol is esterified to cholesteryl ester by acyl-coenzyme A cholesterol acyltransferase-1 (ACAT-1) [ 9].
The PA had excessive accumulation of cholesterol ester (25 30-fold 25 30-foldy acids (8–12-fold), and exhaustiVLCdepletion ofattylesterol (60–70%) acidsphingomyelin (50–55%) in comparison to controls.
