Excessive force generation by airway smooth muscle is the main culprit in excessive airway narrowing during an asthma attack.
In this review we discuss the potential of a new procedure, termed Bronchial Thermoplasty to prevent serious consequences resulting from excessive airway narrowing.
Tracheobronchomalacia (TBM) refers to weakening of the cartilage support of the bronchus or trachea, typically involving the anterior and/or lateral walls, resulting in excessive airway collapse during expiration.
The complex disease asthma, an obstructive lung disease in which excessive airway smooth muscle (ASM) contraction as well as increased ASM mass reduces airway lumen size and limits airflow, can be viewed as a consequence of aberrant airway G protein-coupled receptor (GPCR) function.
Consistent with this, adenosine levels are elevated in the lungs of patients with chronic lung disease [4], [5], [6], where it is hypothesized to regulate the balance between tissue repair and excessive airway remodeling [7].
A chronic moist cough is always abnormal and represents excessive airway secretions [ 41].
Several studies in children indicate that the degree of excessive airway narrowing is modest in patients with CVA.
Two were excluded: excessive airway secretion forcing frequent exchanges of HME filter (G1); length of MV <12 hours (G2).
Excessive airway inflation leads to up-regulation of the genes encoding inflammatory protein expression and mediator secretion by airway cells [ 3].
Similarly, excessive airway inflammation might impair defenses or increase injury during infection (Beisswenger et al. 2006) in the most-responsive group (ESO).
