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A lumbar laminectomy and removal of excessive adipose tissue was performed.
This mismatch caused positive energy balance leading to excessive adipose accumulation [35].
Using TCF8+/− mice, we demonstrate herein that ZEB1 haploinsufficiency elicited excessive adipose tissue accumulation in female mice early in fat acquisition (Figures 2 and 3).
The clinical problem of excessive adipose tissue resides in its strong association with a number of chronic diseases, such as insulin resistance, type 2 diabetes mellitus (T2DM), coronary artery disease and stroke [1].
Obesity is a disease characterized by excessive adipose tissue accumulation in the body.
Obesity is defined by the accumulation of excessive adipose tissue that can contribute to physical and psychosocial impairment.
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Excessive white adipose tissue puts individuals at risk for medical conditions such as Type II diabetes, cardiovascular disease, and cancer.
Other important mechanisms included presence of insulin resistance [ 36– 38], excessive visceral adipose tissue [ 39, 40], activity of circulating dipeptidyl peptidase-4 [ 41, 42] and fatty acid-binding protein-4 [ 43].
From examples mentioned above, one can derive that the initial stages of the pathogenesis of liver fibrosis associated with NAFLD depends primarily on the soluble factors produced by excessive visceral adipose and on a skewed distribution of the soluble fat particles in the bloodstream.
In obesity, the excessive gain of adipose tissue, in particular visceral adipose tissue, causes its dysfunction, which could participate in the development of insulin resistance and other obesity-linked complications such as the NAFLD.
Even a small increase in the amount of adipocyte apoptosis will prevent excessive accumulation of adipose tissue and can result in a significant loss of adipose tissue mass over time.
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