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Evidence for statistically significant excess significance bias was seen for three outcomes (sporadic colorectal adenoma recurrence, Alzheimer's disease, and fractures; supplementary table I).
38 Both the small study and excess significance tests were considered significant at P<0.10, as previously proposed.
28 We also applied the excess significance test, which evaluates whether the observed number of studies with statistically significant results ("positive" studies) differs from the expected number of positive studies, by using a χ test.
Then again, he is sometimes charged with attributing excess significance to such equally unprovable entities as "everyday common sense".
In these cases, one could apply the excess significance test across a collection of several such networks with exchangeable biases.
However, by extension it is possible to apply the arcsine transformation to all the pairwise meta-analyses of a network for the purpose of excess significance testing.
Similar(44)
On the other hand, the power rate was an increasing function of locus effect and/or proportion of causative variants so that it would excess the significance level under the alternative hypothesis.
Consequently, the plausible effects used are conservative in testing for excess statistical significance.
For instance, in an empirical assessment of animal studies of neurological diseases, the strongest excesses of significance were found in meta-analyses where small-study effects were found [ 42].
Notably, there is a significant (P < 0.05, corrected for genome-wide significance) excess of WSB/EiJ alleles spanning a 51.6-Mb genomic region (73.25 124.85 Mb) on chr 2 in the overall set.
In each disorder, there is a significant, or highly significant, excess in the observed number of genes surpassing virtually all thresholds regardless of the method for calculating gene-wide significance.
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