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Statistically significant excess sharing of non-MHC genes was found between type I diabetes (T1D) and all other AID studied, a result also seen for RA.
We developed and implemented a discrete-trait allele-sharing test statistic, Sad, analogous to the Spairs test statistic of Whittemore and Halpern, that evaluates an excess sharing of alleles at autosomal loci in pairs of affected siblings, as well as a lack of sharing in phenotypically discordant relative pairs, where available.
There was no significant evidence of excess sharing of IBD proportion either due to sample contamination, duplication, or cryptic relatedness.
Linkage of chromosomal regions with putative genetic risk factors for a given trait was assessed by evaluating the extent of excess sharing of alleles identical by descent in affected relatives within families.
We simulate a scenario in which there are genotypes showing a high degree of excess sharing of haplotypes.
For example, in Iceland researchers may have been able to localize BRCA2 by studying male breast cancer cases from high-risk families and looking for regions of the genome with excess sharing.
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Individuals who leave less than this are required to pay the full competitive value of their excess share to those deprived of their fair share.
Although the responses to Fe deficiency and excess share components with other stress responses, it does not significantly overlap with one particular stress.
Individuals are morally free to use or appropriate natural resources, but those who use or appropriate more than their per capita share owe others compensation for their excess share.
With reduced consumption, we'll no longer need to fight for an excess share of the world's resources, so we can slim down our bloated military budget.
Glucocorticoids (GC) are implicated in the development of metabolic syndrome, and patients with GC excess share many clinical features, such as central obesity and glucose intolerance.
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Justyna Jupowicz-Kozak
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