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For the upregulated genes, the excess retention (ER) increases as k approaches 30, then drops precipitously around 35 (Fig. 2a).
In order to measure the centrality of the selected set of genes, the excess retention (ER) of the differentially expressed genes was calculated for each k-core.
We used k-core and excess retention (ER) analysis [ 15] to measure the distance between common targets and the topological center.
The excess retention of nodes with property A in the k-core is defined by two steps: (1) computing the proportion of nodes with property A in the whole network (EA = N A/ N) and in the k-core and (2) the excess retention (ER) obtained as.
Analogously, the node based excess retention ER k is defined as ER k = e k, o / E k, where E k is the ratio of all proteins with an ortholog in the whole network.
In this analysis, an increase in excess retention as value of k is increased indicates that the selected group of genes is located near the topological center of the protein network.
Similar(50)
Dilutional hyponatremia is the most common form of hyponatremia and is caused by excess water retention.
The CKD-MBD syndrome characteristic of chronic kidney disease (CKD) of virtually any etiology imposes the burden of excess mineral retention enhancing cardiovascular risk by promoting the development of vascular calcification [ 13, 25– 27].
Hormonal changes that occur during these longer transition periods in the body cause excess fluid retention that may be constant, cyclical or intermittent.
If your attempts to control bloating are not successful or if your excess water retention does not go away when your period begins, see your doctor.
The effects of four variables (food wastes composition in the co-substrate of food wastes and excess sludge, hydraulic retention time (HRT), organic loading rate (OLR), and pH) on acidogenesis were evaluated individually and interactively.
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