Thus our results favor not only local specific functions of GS comprising the production of excess Gln for regional biosynthetic purposes, they also suggest a life-essential role of keratinocytic GS for whole organism in health and disease.
The regional excess hazards varied much more than the expected ones, only small differences in the latter (<2 deaths per 1000 person years) being observed.
Investigation of a regional excess of sinonasal cancer was consistent with studies in other countries showing risks associated with working in the furniture industry (Blot and Fraumeni 1977; Brinton et al. 1976, 1977, 1984, 1985), and study of local lung cancer excess was associated with residence near or employment in the arsenic industry (Blot and Fraumeni 1975, 1994).
In scenario A, the regional excess hazards (also the relative survival ratios) stratified by sex, age group at diagnosis and follow-up time interval were assumed to equal those in the most populated cancer control region, to which Helsinki belongs (region 1).
Given the lack of conclusive evidence of an accidental release of radiation, the Northern Germany Leukemia and Lymphoma study derived estimates of doses from routine operations of the nuclear power facility; the resultant dose estimates are orders of magnitude below the level at which any regional excess of childhood leukemia would be expected (Hoffmann et al. 2003).
Although not all of these studies confirmed the geographically generated hypotheses, investigation of a regional excess of oral cavity and pharynx cancer among women revealed the previously unknown risk of smokeless tobacco use (Blot and Fraumeni 1977; Winn et al. 1981).
These results may suggest that progression of AKI is more likely when higher doses of norepinephrine are required to maintain targeted blood pressure levels in more severely ill patients with severe sepsis, plausibly by causing excess constriction of regional vascular beds [ 29].
Other factors that influence the currents are regional excesses of evaporation or precipitation, regional differences in cooling or heating, friction, and Earth's rotation.
The impacts of climate change on environmental hazards on the Great Hungarian Plain were assessed by calculating the future changes of the most important natural hazards of the region (drought, wind erosion, and inland excess water), based on regional climate model simulation data.
The assertion that there was an unannounced, accidental release of radionuclides in this region (Schmitz-Feuerhake et al. 2005), however, has been an extremely contentious one, leading to dissenting expert opinions from the commissions established to investigate the causes of the regional leukemia excess.
