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We investigated the prevalence and risk factors for excess oxygen exposure (FIO2 > 0.5 despite SpO2 > 92 %).
Recently, a pilot interventional study showed that conservative oxygen therapy in mechanically ventilated patients in the ICU can be feasible and free of adverse outcomes while decreasing excess oxygen exposure [ 96].
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In multivariate analysis, one-lung ventilation was independently associated with greater exposure to excess oxygen (adjusted odds ratio, 12.9; 95%% confidence interval, [7.19-23.1]).
N=3 8 mice per time point per oxygen exposure.
Excess oxygen flow decreases the growth rate.
The flue gas excess oxygen was fixed at 3 vol%.
Gröger, M. et al. DNA damage after long-term repetitive hyperbaric oxygen exposure DNA damage after long-term repetitive hyperbaric oxygen exposure.
Loss of CD73-mediated extracellular adenosine production led to decreased survival with exposure to 95% oxygen, and exacerbated pulmonary inflammation and worsened lung development with 70% oxygen exposure.
In diseases like retinitis pigmentosa (RP), excess oxygen damages these cells.
BALF cell counts were increased in CD73−/− mice in 70% oxygen exposure (Figure 5a).
Oxygen exposure decreases CD73 transcript and protein levels in mice and MLE-12 cells.
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