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A proportion of IBD (PI_HAT) <0.05 was considered to indicate no excess of sharing (i.e. unrelated individuals).
A comparison of signals indicates an excess of sharing at p value thresholds of 0.05, 0.04, 0.03, 0.02 and 0.01 for osteoarthritis and height; there is evidence for overlap between osteoarthritis and BMI at the p value thresholds of 0.005, 0.001 and 0.0005 (table 5).
Similar(58)
Though all humans share derived polymorphisms with Neanderthals, the Eurasian genomes have an excess of shared derived polymorphisms when compared to Africans.
Of the three loci with shared polymorphisms, only lp5 showed a significantly poor fit to the isolation model, with an excess of shared polymorphisms, excess of polymorphisms in loblolly pine, and a lack of fixed differences.
The application of the isolation model (IM) to loblolly pine sequence data revealed some loci (in particular lp5, a drought-response gene) with an excess of shared polymorphism with Scots pine.
Does your hypothesis predict an excess of shared sites around the two sites?
Our findings suggest an excess of shared signals both between osteoarthritis and height and osteoarthritis and BMI.
In any case, the key here is that there was a significant statistical excess of shared U12 introns, much higher than the fraction of shared U2 introns.
The significant excess of shared intron positions over the random expectation can be explained by one of two factors or a combination thereof.
For each pair of species, we tested for an excess of shared X-linked genes using a 2 × 2 contingency table (X, Autosome/Species 1, Species 2).
We found a significant excess of shared signals between both osteoarthritis and height and osteoarthritis and BMI, suggestive of a common genetic aetiology.
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