Numbers needed to treat to harm (NNH), depending on the population at risk, suggest 170 excess myocardial infarctions, 649 excess cases of heart failure, and 431 excess deaths for every 100 000 patients who receive rosiglitazone rather than pioglitazone.
Prof David Webb, president of the British Pharmacological Society, said: "In recent years, those of us who manage the large number of patients at excess risk of heart disease and strokes have been fighting an uphill battle to persuade them to take statins, a class of medicines that have been repeatedly shown to save lives.
However, based on the pathophysiologic consequences of sleep apnea on the cardiovascular system, studies associating excess mortality of heart failure patients with obstructive and central sleep apnea, and limited favorable therapeutic studies, it is important to continue to identify heart failure patients who may suffer from sleep apnea and treat them appropriately.
This can be equated to 649 excess cases of heart failure for every 100 000 patients who received rosiglitazone rather than pioglitazone.
The association, however, lost statistical significance in the fully adjusted model 3. Pioglitazone monotherapy or combination therapy was associated with a non-significant excess risk of heart failure, ranging from 1.17 (0.77 to 1.77) in model 3 to 1.18 (0.88 to 1.57) in model 1.
The second death officially tied to Mr. Cullen came to light after a review of records at Easton Hospital disclosed that the autopsy performed on Ottomar A. Schramm noted an excess of the heart drug digoxin as a "contributing condition" to his death in December 1998, at age 78.
In addition to gender variations in etiological factors and the well-known excess of coronary heart disease in men, differences in access to diagnostic and treatment procedures have been reported.
Indeed, nearly 70% of facilities have a PPV in excess of 70% for heart failure, reflecting the high average of.78 for heart failure in 2006.
In the SAVOR-TIMI trial while no effect on overall CV morbidity and mortality was reported, an excess of hospitalization for heart failure was observed [ 205].
The build up of fatty plaques in blood vessels, which results in atherosclerosis, is a result of the inability of the cells lining the walls of these vessels to cope with too much fat.Fat, and proud of itMore subtly, though, the two researchers have dug up evidence that an excess of lipids damages heart-muscle cells, and even destroys pancreatic cells in rodents.
