It is ironic that the weak and irresponsible gun control laws in states like Florida enable the excess firepower, volume and lethality of guns on the streets, which I believe cause a lot of quite justified fear.
Deinococcus radiodurans, which can absorb IR doses in excess of 5 kGy without lethality (over 1000 times the lethal dose for humans), has become a key model organism for understanding this phenotype (Cox and Battista, 2005, Blasius et al., 2008).
This result suggests that the lethality observed with excess Pab1 is not due to premature stress granules or protein aggregation.
Loss of Mdm2 leads to embryonic lethality due to excess apoptosis, which is completely rescued by concomitant deletion of p53 (Table 1).
In order to avoid possible in utero lethality caused by excess pathway activity, we used the murine PrP promoter element to construct our transgenic lines.
p57Kip2 excess in mice increases embryonic lethality and decreases body size, suggesting that embryonic growth requires accurate control of p57Kip2 dosage.
Additionally, mice lacking Bcl-xL show early embryonic lethality due to the excess apoptosis of immature neurons in brain, spinal cord, and erythroid cells in the liver, indicating the role of Bcl-xL during neuron and erythrocyte maturation (Motoyama et al., 1999; Motoyama et al., 1995).
In contrast to BRCA2 deficient cells, whose growth rate and cisplatin sensitivity are aggravated by RAD51 overexpression [35], excess amount of RAD51 completely rescued the lethality of BRC4-induced cells (Fig. 7B).
lethal dose with 50% lethality.
lethal concentration with 50% lethality.
