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"Millions of patients were exposed to Avandia during 11 years on the market, resulting in 50,000 or more excess heart attacks," he said in an e-mail.
As a consequence, said Dr. Edward Scolnick, the president of Merck Research Laboratories, the company decided to look specifically for excess heart attacks and strokes in a new study it was designing.
The F.D.A. is conducting an estimate of excess heart attacks that might be attributed to the drug, but Dr. Meyer said that the results were not final, declining to disclose the number.
Suboptimal breastfeeding duration in the U.S. results in nearly 5,000 excess cases of breast cancer per year, nearly 14,000 excess heart attacks per year, and over 50,000 excess cases of high blood pressure per year.
Radiation risks now extend to excess heart disease, stroke, digestive diseases and respiratory diseases.
8 41 However, for patients who need thiazolidinedione treatment, continued use of rosiglitazone may lead to excess heart attacks, heart failure, and mortality, compared with pioglitazone.
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The Women's Health Initiative trial reports an excess of heart disease in postmenopausal women receiving MPA.
If you dread this annual exercise in excess, take heart in the rise of the Etsy era, where thriftiness and craftiness are regaining their long-lost luster.
Araneta et al. [ 10] reported significant excess congenital heart defect and hypospadia rates in 11,961 US Gulf war veteran live-born offspring compared with military controls.
Approximately 1,710 excess ischemic heart disease deaths per year would be expected among nonsmoking U.S. workers 35-69 years of age exposed to workplace ETS.
Libby workers experienced no overall excess in heart disease (SMR = 0.9; 95% CI, 0.8 1.1), but they did experience excess mortality from circulatory diseases involving the arteries, veins, and lymphatic vessels (SMR = 1.8; 95% CI, 1.2 2.6; 29 observed vs. 16 expected; ICD-9 codes 415 417, 440 459).
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