Sentence examples for excess copies from inspiring English sources

Large ratios of normalized intensities and/or higher than anticipated heterozygosity at specific genomic locations indicate excessive hybridization and suggest that a duplication, triplication, or other excess copies of the genomic region may exist, whereas small intensity ratios or long runs of homozygosity suggest that a deletion may be present.

The excess copies of rplJ synthesized are rapidly degraded, possibly by specific proteases.

Excess copies of biotinylated oligonucleotides, which are complementary to the 3' end of the fragments to be labeled, were mixed with the sample.

Once a micronucleus is formed and lost during cell division, it becomes inevitable that the surviving cell will turn into a deletion mutant for the genetic materials encapsulated in the MN, unless such genetic materials are excess copies.

To distinguish between these possibilities, we examined 13 BWS patients with excess copies of paternal 11p15.5 (12 patients had paternal UPD and one patient had an 11p15.5 duplication) and two SRS patients with maternal 11p15.5 duplications.

We performed fluorescence in situ hybridization (FISH) experiments using probes against EGFR and PPARGC1A loci to locate their excess copies.

DiNAMIC currently uses the columns sums S j to assess the local evidence for excess copy number gains and losses, and global statistics Tgain X) and Tloss(X) for global testing.

This hypothesis is corroborated by a study showing that an excess of copies of the heterochromatin sequence 1q12 is correlated with global loss of methylcytosine [ 62].

We observed an excess of copy losses (28) and five gains and two regions where both gains and losses were found (Additional file 1: Table S3).

Whole-genome microarray analysis then demonstrated a significant excess of copy number variants (CNVs) in the genomes of both children, compared with a control population, whereas their mother's CNV frequency was not significantly elevated [ 21].

It should be noted that an excess of E2 copy number over E6 copy number is likely to be rare in cervical SCCs and only encountered in cells with high level genomic instability, such as CaSki.