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Finally, as any therapy, under- and over-dosage must be avoided, which implies monitoring nutritional delivery in order to identify a growing energy gap or excess administration.
Importantly, underfeeding and overfeeding must be avoided, which implies monitoring nutritional delivery to timely identify an increasing energy gap or excess administration [ 8].
Fluid creep usually results from inaccuracies in calculating fluid requirement, from clinician inattention to reducing unnecessary fluid infusions, from the increased use of sedation and analgesic infusions, and from the excess administration of crystalloid in favour of colloid replacement - or a combination.
Kochhar (Kochhar, 1967) and Yasuda et al. (Yasuda et al., 1990) were the first to report that excess administration of RA to pregnant mice could lead to caudal malformations in the offspring, and Padmanabhan (Padmanabhan, 1998) later reported that this treatment could also cause sirenomelia.
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Myocardial edema due to excess fluid administration compounds the myocardial dysfunction common in critically ill patients [21].
To avoid excess fluid administration, an increase of CO in response to maneuvers such as the passive leg raise (PLR) is considered indicative of fluid responsiveness [7].
Twenty-four hours after exposure, they were sacrificed by excess pentobarbital administration.
Myocardial edema due to excess fluid administration compounds the myocardial dysfunction common in critically ill patients [ 21].
Both excess RA administration and vitamin A deficiency can disturb cardiac looping in embryos [ 32, 33, 45, 46].
To investigate the molecular mechanisms of Dex-induced osteoporosis, we first established a mouse osteoporotic model by excess Dex administration (50 mg/kg daily) for 5 weeks.
As already noted, the genesis of hyperchloremic metabolic acidosis stems from excess chloride administration relative to sodium, commonly as 0.9% normal saline solution, 0.45% normal saline solution, and even LR solution in large quantities [ 24- 26].
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