Exact(3)
One of them, namely [l-1-Nal2,Vappears, which apracticallytically not to interact with V1a and V2 receptors, is exceptionally selective.
Using this approach, we obtained compound Aba[ cis-Apc,Val]AVP (XI) which turned out to be a moderately potent and exceptionally selective OT antagonist (pA2 = 7.26).
Moreover, it should be emphasized that the presence of a bulky acyl substituent at the N-terminus of [ cis-Apc,Val]AVP significantly improved selectivity of the resulting analogues and led to compound XI (Aba[ cis-Apc,Val]AVP) which is a moderately potent and exceptionally selective anti-oxytocic agent.
Similar(57)
We report exceptionally strong selective changes at the Pan I locus which is involved in habitat selection of depth by genotype in populations of Atlantic cod at Iceland.
Made famous by the writings of Charles Fox and Vincent Marinaro, anglers nationwide would descend on this gentle limestone creek for the privilege to cast to its exceptionally large and selective brown trout.
A derivative of the native polyamine toxin, philanthotoxin-56 (PhTX-56), has recently been shown to be an exceptionally potent and selective antagonist of Ca2+-permeable AMPA receptors.
The first defining feature of the last six months would seem to be that the grim reaper has been both exceptionally busy and horribly selective.
The concurrent implementation of a proteome-wide serine hydrolase selectivity screen with traditional efforts to optimize fatty acid amide hydrolase (FAAH) inhibition potency led to the expedited discovery of a new class of exceptionally potent (Ki < 300 pM) and unusually selective (>100-fold selective) inhibitors.
New York exceptionalism--exceptionally dangerous, exceptionally grouchy, exceptionally dirty--has been replaced by a well-scrubbed homogeneity.
The technique, called microenvironmental selective plane illumination microscopy (meSPIM), uses exceptionally long, thin beams of laser light to trigger fluorescence in a sample, causing it to glow.
EI1 was about 90-fold more selective for EZH2 over EZH1 and exceptionally more selective (>10 000 fold) for EZH2 over 10 other methyltransferases.
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