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An exceptionally low frequency of LGRs in these two genes (<1.5%) was reported in a study of the Spanish population [ 18], though a higher frequency of LGRs was found in a Basque Country population [ 19].
Moreover, it is noteworthy that an exceptionally low frequency of large rearrangements in the MLH1 and MSH2 genes (<1.5%) was also reported in a study of the Spanish population [ 11]; indeed, due to historical inheritage Spaniards share a common genetic pool with the Southern Italian population.
In agreement with this expectation, one study uncovered two high-risk host genotypes and one potentially protective genotype within the Japanese population; 95% of the population was found to have one of the two risk genotypes and 56% were found to have both, while there was an exceptionally low frequency of the protective genotype (Saeki et al. 2013).
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Five species [cryptic species (CSP) 8, 9, 10, 18 and 19] occurred at exceptionally low frequencies in the collection sites and represented less than 3% of all collected strains.
As a result of their anatomical modifications, howler monkeys produce exceptionally low-frequency vocalizations for their body size compared with other mammals.
Here, we set out to test the relative variation in recombination frequencies among genes for bacterial genomes with an overall exceptionally low recombination frequency.
However, such repeats containing more than two microsatellites were exceptionally low in frequency in the insect genomes (data not shown).
Our design overcomes pathological circumstances such as hidden and exposed terminals that arise due to carrier sensing and are exceptionally problematic in low frequency bands.
However, there is support for fitness disadvantages or at least exceptionally low observation and capture frequencies in the more eumelanized morph unrelated to direct natural selection pressures on colour (e.g. predation or thermoregulation) in other bird species [58; see however 12] and also in mammals [59,60] and insects [15].
However, in the case of independent domestication a high frequency would be anticipated also in the neighbouring regions, but instead the frequency of HG23 was exceptionally low in, for example, Europe (6%).
Thus, although the frequency of alternative splicing at NAGNAG sites is exceptionally low in C. elegans (20-fold lower compared to humans), those that are alternatively spliced have the same characteristics as in humans.
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