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Here we show that exceptionally frequent single-base mutations occur in these genes in multiple cancer types.
Increased congenital heart disease and other major anomalies are exceptionally frequent in children with trisomy 21.
Mutations of p53 are exceptionally frequent in TNBC (>80%) and its inactivation predicts poor survival in TNBC patients [ 10, 12].
TP53 mutations are exceptionally frequent in cancer and are among the key driving factors in TNBC [ 18].
Strengths of the study were that it was population-based and children were measured by trained personnel, with exceptionally frequent follow-up throughout childhood.
In particular, TP53 mutations are exceptionally frequent and apparently among the key driving factors in triple negative breast cancer —the most aggressive breast cancer subgroup whose management still represents a clinical challenge.
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The node degree distribution for the network approximated a power-law distribution (Additional file 2: Figure S7), an inherent characteristic of scale-free networks, indicating the presence of few exceptionally connected genes in contrast to more frequent less connected genes.
New York exceptionalism--exceptionally dangerous, exceptionally grouchy, exceptionally dirty--has been replaced by a well-scrubbed homogeneity.
The 2007 storm was exceptionally damaging, but severe storms are becoming more frequent, according to a state report on climate change submitted in January to the Iowa Legislature and governor.
In the 1950's a Finnish researcher noticed that lumberjacks in North Karelia suffered frequent heart attacks despite jobs that kept them exceptionally fit.
Activity at caldera volcanoes, on the other hand (i.e. Taupo, Okataina and Mayor Island), is characterised by far less frequent (on average every 1000 2000 years), moderate to exceptionally large sized eruptions.
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