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While much has been learned using these pore-blocking toxins in subsequent years, and X-ray structures of ion channel proteins now seem to abound, it has turned out to be exceptionally difficult to solve the structure of an ion channel with a toxin bound to it.
Similar(59)
The problem was too difficult to solve.
This simple problem is surprisingly difficult to solve.
Generally, they are very difficult to solve.
Such systems are often difficult to solve.
They are difficult to solve exactly.
The problem of displaced persons is particularly difficult to solve.
It's not difficult to solve.
Other problems are more difficult to solve, however.
It is really quite difficult to solve that problem.
It is difficult to solve in practice.
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