An equilibrium between the A- and the D-forms of the enzyme (greatly shifted to the latter one) was reached in the absence of any ligands and the rate of equilibrium was exceptionally temperature-dependent (negligible at 15 20°C but significant at 30 37°C).
The regulation of this degradation has been found to be exceptionally complex and dependent on a multitude of cellular inputs.
These properties suggest that CaV2.1 furnishes exceptionally strong activity-dependent enhancement of Ca2+ entry throughout the nervous system, with important repercussions for downstream Ca2+-dependent processes like neuronal plasticity.
How is it that we accept completely unknown data being shoveled through black box algorithms we know absolutely nothing about, performing analyses that we know are exceptionally nuanced and entirely dependent on the decisions of their creators?
Nothobranchius furzeri show an exceptionally short lifespan, age-dependent cognitive/behavioral decline, expression of age-related biomarkers, and susceptibility to lifespan manipulation.
The best predictor for renal survival was renal function at diagnosis: recovery of renal function in dialysis dependent patients is exceptionally rare [ 7, 10, 40] as well as in those with serum creatinine exceeding 500 μmol/l despite undergoing treatment [ 6, 7, 10- 12, 34].
ITC has proven exceptionally useful for quantifying composition-dependent phenomena in aqueous surfactant solutions, including membrane solubilization and reconstitution, partitioning and translocation, permeabilization, and curvature strain.
The Methanosarcina species possessed an exceptionally large number of B12-dependent methyltransferases, including MtaABC, MtmABC, MtbABC, MttABC, MtsABC and MtrAB (e.g., totally 15 methyltransferases in M. acetivorans and 12 in M. mazei).
Several recent academic studies confirm that countries whose economies are dependent on oil exports show exceptionally low living standards; exceptionally high rates of child mortality, malnutrition and income inequality; low rates of literacy and life expectancy; and unusually high rates of corruption, authoritarian government, military spending and civil war.
