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In a previous report, three mAbs against MERS-CoV RBD with exceptional potency was found to originate from the IGHV1-69 heavy chain family57.
All of the title compounds have considerable activity against the twelve strains, and exhibit exceptional potency in inhibiting the growth of Staphylococcus aureus, Staphylococcus epidermidis and Klebsiella pneumoniae (minimum inhibitory concentration (MIC): 0.06 8 μg/mL).
The exceptional potency and breadth of 3BNC117 set off a number of collaborative studies to investigate its in vivo therapeutic effect (see the figure, parts D and E).
These have evolved from rational drug development, which has generated inhibitors with exceptional potency and specificity [ 2].
The first human neutralizing mAb, m101, with exceptional potency against HeV and NiV, was identified in 2006.
Metformin shares biguanide functional groups in common with protease inhibitors, and metformin has demonstrated protease inhibitor activity with exceptional potency at therapeutic concentrations [ 9].
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The designed PIs retain robust binding to MDR protease variants and display exceptional antiviral potencies against different clades of HIV as well as a panel of 12 drug-resistant viral strains.
Their exceptional in vivo potency is at least in part due to their ability to mimic the site and location of mitochondrial superoxide dismutase, MnSOD.
Recently we described a novel class of imidazopyridine compounds that showed exceptional anti-RSV potency in cell culture.
Based on its exceptional kinase selectivity, great potency and metabolic stability, 15l represents a promising lead for the discovery of RET directed therapeutic agent and should be a key tool in studies aimed at understanding RET biology.
This manuscript describes a number of 8-hydroxyquinoline tetracyclic lactams with exceptional antiviral activity against HIV-1 and little loss of potency against the IN signature resistance mutations Q148K and G140S/Q148H.
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