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Mouse lemurs have an exceptional lifespan compared to other mammalian species of similar size, such as rodents.
Interestingly, the authors observed that while long telomeres might be a prerequisite for exceptional lifespan in humans, they did not predict mortality.
They have a similar number of known disease-associated variants to other genomes showing that their exceptional lifespan does not seem to be due to lack of known disease-associated variants.
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Due to its exceptional short lifespan, this killifish species is very suitable to study the impact of aging on regenerative processes.
As he notes: "The unity of the British Isles, so far from being the norm, can appear rather as an exceptional condition, with a lifespan of less than 200 years, from the Battle of Culloden, say, in 1746, to the Irish Treaty of 1921".
Moreover, long telomeres have been associated with exceptional longevity and increased lifespan [ 21].
At Smithsonian National Zoo, a female oryx died at 21, an exceptional age since females generally have a lifespan of about 15 years.
The genetic contribution to lifespan grows markedly after age 60, indicating the heritability of exceptional longevity may be substantially higher than these estimates [20].
Thus, identifying those genetic variants that are associated with exceptional longevity and rate of decline of physical function at the end of the human lifespan is of potential medical relevance.
Hence, genomic studies into aging thus far focus on the determinants of human lifespan variation by using age at death, prospective survival, disease-free survival, or exceptional longevity as outcome.
Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com