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Perhaps, these exceptional gene expression biases indicated an additional level of gene expression regulation such as DNA methylation.
It is interesting to find the MICA-based methods can be also applied to achieve exceptional gene expression pattern classification and meaningful biomarker discovery [ 22].
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The exceptional performance of gene expression regulation on chromosome 19 was very similar among the four aneuploid samples, with less than 10% of genes up-regulated and more than 20% down-regulated (as high as 35% in monosomy X).
Due to the exceptional performance of gene expression regulation on chromosome 3 in trisomy 22 and chromosome 10 in trisomy 8, we performed a functional clustering compared with chromosome 22 in trisomy 22 and chromosome 8 in trisomy 8, using chromosome 1 as a control.
Female ruminants are exceptional in exhibiting high INSL3 gene expression by the thecal cells of antral follicles and by the corpora lutea.
CpG islands (CGIs), central to the regulation of mammalian gene expression, are exceptional in terms of whether, when and how they are affected by epigenetic reprogramming.
There is no obvious reason one line should be so much less variable than the others, but the presence of MA lines with extreme phenotypic values is the norm in MA experiments (e.g., [17]) and there is no obvious reason to expect that environmental variation in gene expression should be exceptional.
It has also been reported that in exceptional cases miRNA can up-regulate gene expression [ 4] but the manner in which this happens is even less understood.
The mild dysplasia-derived cell line (DOK) and an OSCC-derived cell line (PE/CA PJ15) were exceptional in having very high ABCG2 gene expression relative to control (OKF6-TERT2); anOSCC-derivederived cell line (SCC04) gave the lowest relative expression of ABCG2 (Table 2).
In exceptional cases, in particular, they can also up-regulate gene expression.
In addition, the salivary glands of Chironomus tentans (Ch. tentans) constitute an exceptional experimental system for in situ analyses of gene expression.
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