These results also show that while a core group of conserved residues deep in the receptor-binding pocket have unusually low mutational tolerance, the bulk of residues that contact the receptor are not under exceptional constraint.
We then describe results that validate this hypothesis, and conclude: "These results also show that while a core group of conserved residues deep in the receptor-binding pocket have unusually low mutational tolerance, the bulk of residues that contact the receptor are not under exceptional constraint.
10 Iranian women encounter exceptional social and cultural constraints, such as disagreement with their spouse or father about going to gyms or their participation in PA.
Given this data, modelling approaches can be used to optimally allocate resources between routine and exceptional responses given the logistical constraints of each resource.
In spite of its significant health systems constraints, Malawi has made exceptional progress in expanding access to ART.
It usually consists of a small team taken out of their normal working environment and given exceptional freedom from their organisation's standard management constraints.
The critical Reactive Centre Loop (RCL) sequence, including the target proteinase cleavage site, is strongly conserved in inhibitory serpins, although there are 3 exceptional sets of orthologues in which the evolutionary constraints are looser.
Budget constraints for the bird project were such that exceptional measures to achieve long-range contiguity could be applied only to a select subset of species.
Fully illustrated with rarely published archival drawings and plans, accompanied by the author's own exceptional photographs, this book presents the spectrum of architectural responses to the constraints of site, climate, client, program, building material, region, and nation.
"It would be worth exploring the possibility of establishing new formulas that would allow... exceptional mechanisms to prevent the minimum wage from acting as a constraint".
