As some phosphosites are weakly supported and may have resulted from faulty identification, we limited the analysis to proteins that have >5 independent supporting observations from the literature (Additional file 1). Figure 4 illustrates a focused view of 5 representatives from the exceptional cluster-rich proteins.
Exceptional familial clusters of extreme longevity have also been reported (Perls et al. 2000).
In the case of SARS in Hong Kong, our study, first and foremost, demonstrates exceptional spatial clustering of the cases.
The total (haploid) numbers of rDNA clusters varied between two, three, and six (in one exceptional case), and clusters were localized either on the autosomes, the sex chromosomes, or both.
In this regard, it is noteworthy that the occurrence of two mbtH genes in a secondary metabolite gene cluster is exceptional in that it has only been found once before in the teicoplanin biosynthesis gene cluster of Actinoplanes teichomyceticus [ 86].
Thus, as with most centenarians, and particularly those beyond the age of 103 years [ 12], LLFS members of families that cluster for exceptional longevity not only live longer but also have extended health-spans.
The NGI was created to combine existing strengths into one initiative composed of core activities (Centres of Excellence, Innovative Clusters, Technology Centres, Exceptional Talent, International Research Consortiums, and Innovate Genomics Clusters) and research programs [ 31].
The abundance distributions for several kinds of clusters show that there are certain sizes of clusters with exceptional stability, analogous to the exceptional stability of the atoms of the inert gases helium, neon, argon, krypton, and xenon and of the so-called magic number nuclei i.e., the sequence of unusually stable atomic nuclei beginning with the α-particle, or helium nucleus.
Polyoxometalates (POMs), an exceptional family of coordination clusters consisting of Mo, W, V, etc. early transition metal ions in their highest oxidation states, have received significant attention over recent years due to their structural versatility and unique and diverse chemical and physical properties.
The exceptional sequence conservation and clustered structure suggests that UCR-mediated molecular events involve greater complexity than traditional DNA binding by transcription factors.
