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For many years the extranuclear functions of HMGB1 were little studied (with the notable exception of studies on amphoterin, the other name of HMGB1, by Rauvala and coworkers [4]), until Wang et al. [5] strikingly showed that, in addition to its nuclear functions, HMGB1 was involved in sepsis as a late mediator of endotoxin lethality in mice.
With the arguable exception of studies of Mars, deepening knowledge about the solar system is not as glamorous an activity as widening it.
We searched MEDLINE for reports published in English up to November, 2017, using the terms "scaffold free", "scaffold less" and "cartilage repair", with the exception of studies using simple intra-articular cell injection.
In addition, data on chromosomal mosaicism frequencies in phenotypically normal individuals, with the exception of studies in reproductive tissues [13], is sparse as well [11], [21].
To date, evidence linking gap junction remodeling with ventricular dysfunction has been correlative, with the exception of studies done on chimeric mice, composed of variable mixtures of Cx43-null and wild-type cells throughout all tissues of the body [32].
Surprisingly little is known about the malaria infection and disease epidemiology in the semi-arid settings of the East and Horn of Africa, with the exception of studies in Eastern Sudan [5] [8].
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Until recently, the prevailing model for p53 function has been studied primarily within the nucleus with the exception of studying the stability of the p53 protein itself.
Metaregression found no effect of any other variables abstracted on summary outcomes, with the exception of study duration.
The volunteers were instructed to drink no alcohol or high-energy products during each study period with the exception of study treatment.
Most QLQ-C30 responses were >90%% complete at baseline (Additional file 2: Table S1) with the exception of study 10 (about 60%% complete).
With the exception of study by Tricklebank et al. [ 30], total [Trp] values in pregnancy ranged between 25 and 47 μM.
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