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With the increase of sample sizes from 400 to 2000, both power and type I error rates tended to increase in all analytical methods except for PCA.
For all calculations, except for PCA and for obtaining the data displayed in Table 1, images were preprocessed with a lanczos/sinc window function to reduce spectral leakage and wrap around effects.
With the increase of frequencies of disease susceptible allele from 0.01±0.02 to 0.04±0.02, we observed a consistent decrease of type I error rates in all analytical methods except for PCA, which attained much lower type I error rates than other analytical methods.
YW, CJS, AMB, HRS conceived the ideas; YW, CJS collected or arranged for the materials; AMB, YW, JAL developed the markers; YW, AMB developed the sequence matrix; HRS analyzed the data except for PCA; AMB developed and performed PCA; HRS, JAL, YW wrote the paper; CJS and GYZ managed the project.
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ODNs for LCR are the same as those for PCA except that each strand is 5' phosphorylated for ligation.
Theme 3 - Use of the Internet for information retrieval The men often used the Internet for PCa information retrieval except for man F, who relied on his spouse to get such information.
Previously untreated for PCa.
Patients retained for PCA with all the four prospective measurement times were similar to those excluded except that they seem to be older (data not shown).
PCA methods can be implemented using the functions acp and pca for PCA, acpgen for Generalized PCA, and acprob for Robust PCA.
Genes such as CLU, PEG3 etc. that are suppressed by AR are up regulated (except for NDRG1) in human PCa cells, and in the LNCaP model.
We did not find any evidence of effect modification (interaction p-values > 0.2, data not shown) except for family history of PCa and PCB-153 exposure (see Supplemental Material, Table S5).
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