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In group B, no significant changes were observed in mitochondrial damage between preischemia and repefusion biopsies (except for grade 0).
Control subjects were eligible only when they were devoid of any systemic diseases except for grade 1 hypertension (SBP < 160 mmHg and DBP < 100 mmHg) [16] and migraine.
Maximum tolerated dose (MTD) was not reached, and except for grade 3 mucositis in 4 patients, no other significant unexpected non-hematologic toxicities have occurred indicating safety of this regimen.
Aggregate numbers of absences by grade are shown in Figure 1, except for grade 12, which was involved in an independent study project so those students were not generally present at school.
Imputation variables were complete, except for grade and oestrogen receptor status (used in imputation models only).
Relationships between factors were measured using the nonparametric Mann-Whitney test, except for grade where Jonckheere-Terpstra trend analysis was applied.
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No association was found between the presence of PDGFRA gene amplification and expression, excepting for grade II diffuse astrocytomas.
In Orthodox schools, the Greek language would be the sole medium of instruction, except for grades one through three.
If any other Grade 3/4 toxicity (or Grade 1 thrombocytopenia) occurred, treatment was delayed for 1 week and was then restarted at 19 μg m−2 if recovery had occurred to Grade ⩽1 (except for thrombocytopenia (Grade 0) and neutropenia (Grade 2)).
Nonhaematological toxicities were CTCAE grade 1 2, except for two grade 3 events: one hypersensitivity reaction in patient 4 after i.v. paclitaxel administration, and muscular weakness in patient 1, that was considered to be probably related to SMEOF#3.
All IRRs were grade 1 or 2, except for 3 grade 3 IRRs associated with Infusion 1 and 2 grade 3 IRRs associated with Infusion 2. Four patients experienced a total of 5 grade 3 IRRs; 3 of these patients continued on to received subsequent infusions at the faster rate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com