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The reaction is successfully performed under mild conditions to afford good to excellent yields of the products.
This reusable solid catalyst exhibited excellent activity and the methodology is applicable to diverse substrates providing good to excellent yields of desired products.
An intermediate, pyridinyl substituted thiazolyl acid hydrazide (4) when condensed with benzoic acids/nicotinic acids (5a o) in the presence of silica supported POCl3 yielded better to excellent yields of the title compounds.
This method provides excellent yields of the products with high selectivity.
Changing the base from KHMDS to NaHMDS or LHMDS also afforded excellent yields of cyclization (Table 1, entries 8 and 9).
Almost all aldehydes provided good to excellent yields of the products irrespective of the position as well as electron donating and withdrawing nature of the group in the aryl aldehydes (Scheme 1).
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The catalytic system was optimized with respect to various reaction parameters to give excellent yield of desired products.
Other remarkable features include the wide range of functional group tolerance (46 quinazolinones are synthesized and 9 of them are reported firstly), and providing moderate to excellent yield of the products under mild conditions.
The advantages of the present protocol include the use of green catalyst, easy isolation of the products, reusability of catalyst, absence of nontoxic reagents, and excellent yield of the products.
The experiments showed that excellent yield of middle distillate products can be obtained from the bio-derived syngas, but it required supplementing the syngas with hydrogen due to low H2/CO ratio.
The conversion yield from 4-NP to 4-AP was measured by RP-HPLC with an excellent yield of 99.8%.
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