During growth there may be a positive BMU balance, with bone formation exceeding bone resorption.
At endosteal sites distant from bone erosions, bone turnover was far lower (6%) and again bone formation exceeded bone resorption.
Thus, ovariectomy-induced bone loss, a model of postmenopausal osteoporosis, results from an acceleration of osteoclastic bone resorption, followed by high bone turnover in which bone resorption exceeds bone formation.
Osteoporosis is a bone disease in which bone resorption exceeds bone deposition, resulting in bone loss [ 6].
Estrogen deficiency at menopause or androgen deficiency in men results in an unbalanced increase in bone turnover, such that bone resorption exceeds bone formation.
Osteoporosis is a chronic, progressive bone disease in which bone resorption exceeds bone formation, leading to a reduction in BMD, disruption of bone microarchitecture and increase in fracture risk.
Osteoporosis is a metabolic bone disorder defined as "a skeletal disease, characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture". 1 In the elderly, with decreasing levels of estrogen and testosterone, bone resorption exceeds bone formation; thus, the risk of osteoporosis increases.
Anti-resorption agents are considered in the rebuilding of the bone remodelling balance because postmenopausal osteoporosis (type I) is characterised by bone resorption that exceeds bone formation.
Estrogen levels decline progressively in postmenopausal women and cause a state of negative metabolic balance in which bone resorption often exceeds bone formation, thereby decreasing bone mass.
Osteoporosis results when bone resorption and bone formation are imbalanced and excess bone breakdown exceeds bone building [ 2].
