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Unfortunately, survival has not improved during the past decade as MPM is exceedingly resistant to most chemotherapy regimens.
As shown, 2-DG treatment induced ATP depletion in MiaPaCa-2 cells in a time- and concentration-dependent manner, whereas Capan-2 cells were exceedingly resistant to 2-DG under these conditions.
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Tumors that recur post-therapy are often exceedingly aggressive and resistant to subsequent therapeutic interventions.
In the region surrounding our study site, the Umzinyathi district of KwaZulu-Natal, South Africa, drug-resistant TB is exceedingly common: approximately one in three people with culture confirmed TB have MDR-TB and one in six have extensively drug resistant (XDR -TB [ 10].
Verified resistance to spectinomycin is exceedingly rare worldwide with only five spectinomycin-resistant isolates (all between 1988 and 1990) identified in the US Gonococcal Isolate Surveillance Project [ 20] using the CLSI recommendation.
In addition to its many adverse effects that must be addressed, treatment is exceedingly long, reports of relapses are frequent, and drug-resistant ML strains have emerged (Prasad and Kaviarasan, 2010).
Additionally, it has been shown that such agents are exceedingly effective at blocking the proliferation of models that are resistant to endocrine therapy, probably because CDK4/6 is downstream of multiple pathways (for example, Her2 and PI3K) that are implicated in the bypass of endocrine therapy [ 70, 72, 73].
The adult heart is famously resistant to forced hyperplasia, and tumors of myocardial origin are exceedingly rare.
Given the exceedingly poor prognosis, it is critical to understand the biology of treatment-resistant glioblastoma cells.
Exceedingly harsh!
Dress was exceedingly casual.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com